Loss of Endogenous Bone Morphogenetic Protein-6 Aggravates Renal Fibrosis
نویسندگان
چکیده
منابع مشابه
Role of bone morphogenetic protein-7 in renal fibrosis
Renal fibrosis is final common pathway of end stage renal disease. Irrespective of the primary cause, renal fibrogenesis is a dynamic process which involves a large network of cellular and molecular interaction, including pro-inflammatory cell infiltration and activation, matrix-producing cell accumulation and activation, and secretion of profibrogenic factors that modulate extracellular matrix...
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BACKGROUND Effective treatments for fibrotic diseases such as idiopathic pulmonary fibrosis are largely lacking. Transforming growth factor beta (TGFβ) plays a central role in the pathophysiology of fibrosis. We hypothesized that bone morphogenetic proteins (BMP), another family within the TGFβ superfamily of growth factors, modulate fibrogenesis driven by TGFβ. We therefore studied the role of...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2011
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2010.12.005